Antimicrobial α-defensins as multi-target inhibitors against amyloid formation and microbial infection
نویسندگان
چکیده
منابع مشابه
Dual inhibitors of β-amyloid aggregation and acetylcholinesterase as multi-target anti-Alzheimer drug candidates.
Notwithstanding the functional role that the aggregates of some amyloidogenic proteins can play in different organisms, protein aggregation plays a pivotal role in the pathogenesis of a large number of human diseases. One of such diseases is Alzheimer's disease (AD), where the overproduction and aggregation of the β-amyloid peptide (Aβ) are regarded as early critical factors. Another protein th...
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The first cyclic peptide discovered in animals is an antimicrobial octadecapeptide that is expressed in leukocytes of rhesus monkeys. The peptide, termed rhesus θ-defensin 1 (RTD-1) is the prototype of a new family of antimicrobial peptides, which like the previously characterized αand β-defensin families, possesses broad spectrum microbicidal activities against bacteria, fungi, and protects mo...
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Several natural and synthetic flavone derivatives have been reported to inhibit formation of amyloid fibrils or to remodel existing fibrils. These studies suggest that the numbers and positions of hydroxyl groups on the flavone rings determine their effectiveness as amyloid inhibitors. In many studies the primary method for determining the effectiveness of inhibition is measuring Thioflavin T (...
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Running title: Entacapone and Tolcapone inhibit Syn fibrillization * To whom correspondence should be addressed: Prof. Hilal A. Lashuel; Fax: +41 1 693 17 80; Email: [email protected]. Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer’s disease (AD). There is considerable consensus that the increased production and/or aggregation of α-synuclein (α...
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Alzheimer’s disease (AD) is a neuroinflammatory based pathologic state in which β-amyloid aggregates are a major devastating agents. In this study, a series of 2-hydroxyiminoethanones were synthesized and evaluated as anti-inflammatory in carrageenan and formalin tests and inhibitors of β-amyloid aggregation. Compounds 1-10b were synthesized through a two-step reaction. Results: Compounds 1-5b ...
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ژورنال
عنوان ژورنال: Chemical Science
سال: 2021
ISSN: 2041-6520,2041-6539
DOI: 10.1039/d1sc01133b